Julie-Anne Manning commenced her cello studies at the Royal Irish Academy of Music in Dublin with Nora Gilleece, and later with William Butt. She then moved to London to study at the Royal Academy of Music under the guidance of Professors David Strange and Felix Schmidt. For her final recital she was awarded the overall string prize and the RAM Diploma for an outstanding degree. Other prizes awarded to Julie-Anne during her time at the Academy include the Rose Roitman Award, Sir John Barbirolli Prize, MBF Ian Fleming Award and the Harold Craxton Prize. 
Julie-Anne enjoys performing recitals, concertos, and taking part in chamber groups. She has performed recitals and chamber concerts in venues including the Wigmore Hall, St. James Piccadilly, National Concert Hall, Dundalk Town Hall, National Gallery, Kings Place, Endellion Festival, West Cork Chamber Music Festival, Anaverna House and the Bridgewater Hall. She regularly performs with the Manning Trio and the Rossi Quartet.

Julie-Anne has toured extensively in her career and has worked with many orchestras, including the Philharmonia, London Symphony Orchestra, BBC Philharmonic, Opera North and Northern Sinfonia. She has performed as principal cellist of Camerata Ireland and the RTE Concert Orchestra, and was principal cellist of the European Union Youth Orchestra for two years. She is presently a member of the world-renowned Hallé Orchestra.